H. pylori infection is the principal cause of gastritis, peptic ulcer and gastric cancer. H. pylori infection slowly induces chronic gastritis which progresses through the premalignant stages of atrophic gastritis, intestinal metaplasia, dysplasia, and finally to gastric cancer.
Interestingly, only 1% of patients who are diagnosed as H. pylori-positive develop gastric cancer, but 70–80% of patients with gastric cancer have H. pylori. Therefore, early H. pylori eradication is a reasonable approach to improve dyspeptic symptoms, reduce the risk of recurrent peptic ulcers and prevent gastric cancer.
Emeritus Professor Dato' Dr Goh Khean Lee
Special Consultant Gastroenterologist and Hepatologist
University Malaya Medical Centre
Cengiid Medical Centre
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